bs-6518C
[Life Science]
bvt-2733
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 428.96
Formula: C17 H21 Cl N4 O3 S2
CAS Number: 376640-41-4
InChi Key: YDPRNGAPPNPYQQ-UHFFFAOYSA-N
InChi: InChI=1S/C17H21ClN4O3S2/c1-12-14(18)4-3-5-15(12)27(24,25)20-17-19-13(11-26-17)10-16(23)22-8-6-21(2)7-9-22/h3-5,11H,6-10H2,1-2H3,(H,19,20)
Smiles: CN1CCN(CC1)C(=O)CC1=CSC(NS(=O)(=O)C2C=CC=C(Cl)C=2C)=N1
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power
Shelf Life: 1.0 years
Formula: C17 H21 Cl N4 O3 S2
CAS Number: 376640-41-4
InChi Key: YDPRNGAPPNPYQQ-UHFFFAOYSA-N
InChi: InChI=1S/C17H21ClN4O3S2/c1-12-14(18)4-3-5-15(12)27(24,25)20-17-19-13(11-26-17)10-16(23)22-8-6-21(2)7-9-22/h3-5,11H,6-10H2,1-2H3,(H,19,20)
Smiles: CN1CCN(CC1)C(=O)CC1=CSC(NS(=O)(=O)C2C=CC=C(Cl)C=2C)=N1
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
BVT-2733 is a selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, which attenuates obesity and inflammation in diet-induced obese mice. BVT-2733 protects osteoblasts against endogenous glucocorticoid induced dysfunction. BVT-2733 exhibits an anti-inflammatory effect on CIA. This protective effect is, at least partly, mediated by inhibition of the NF-κB and NLRP1 inflammasome signaling pathways. 11β-Hydroxysteroid dehydrogenase 1 (11β-HSD1) plays an important role in inflammation. 11β-HSD1 inhibition may represent a potential therapeutic target for RA patients.
Size: 10mg solid, 2mg solid 10mg solid, 2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.