bs-6497C
[Life Science]
CGP-57380
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 244.23
Formula: C11 H9 F N6
CAS Number: 522629-08-9
InChi Key: UQPMANVRZYYQMD-UHFFFAOYSA-N
InChi: InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
Smiles: NC1N=CN=C2NN=C(NC3C=CC(F)=CC=3)C2=1
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power
Shelf Life: 1.0 years
Formula: C11 H9 F N6
CAS Number: 522629-08-9
InChi Key: UQPMANVRZYYQMD-UHFFFAOYSA-N
InChi: InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
Smiles: NC1N=CN=C2NN=C(NC3C=CC(F)=CC=3)C2=1
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
CGP-57380 is a selective inhibitor of MAP kinase-interacting kinase 1 (MNK1) in vitro (IC50 = 2.2 μM). MNK1 overexpression was confirmed in both primary GBMs and glioma cell lines. Inhibition of MNK1 activity in GBM cells by the small molecule CGP-57380 suppressed eIF4E phosphorylation, proliferation, and colony formation whereas concomitant treatment with CGP-57380 and the mTOR inhibitor rapamycin accentuated growth inhibition and cell-cycle arrest.
Size: 10mg solid, 2mg solid 10mg solid, 2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.