bs-6489C
[Life Science]
AHU-377 hemicalcium salt
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 861.04
Formula: C48 H56 Ca N2 O10
CAS Number: 1369773-39-6
InChi Key: DDLCKLBRBPYKQS-OXXXZDCLSA-L
InChi: InChI=1S/2C24H29NO5.Ca/c2*1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19;/h2*4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28);/q;;+2/p-2/t2*17-,21+;/m11./s1
Smiles: [Ca+2].C[C@H](C[C@@H](CC1C=CC(=CC=1)C1C=CC=CC=1)NC(=O)CCC([O-])=O)C(=O)OCC.C[C@H](C[C@@H](CC1C=CC(=CC=1)C1C=CC=CC=1)NC(=O)CCC([O-])=O)C(=O)OCC
Purity: 98.0
Solubility: Soluble in DMSO (10 mg/mL) and in ethanol (5mg/mL).
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C48 H56 Ca N2 O10
CAS Number: 1369773-39-6
InChi Key: DDLCKLBRBPYKQS-OXXXZDCLSA-L
InChi: InChI=1S/2C24H29NO5.Ca/c2*1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19;/h2*4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28);/q;;+2/p-2/t2*17-,21+;/m11./s1
Smiles: [Ca+2].C[C@H](C[C@@H](CC1C=CC(=CC=1)C1C=CC=CC=1)NC(=O)CCC([O-])=O)C(=O)OCC.C[C@H](C[C@@H](CC1C=CC(=CC=1)C1C=CC=CC=1)NC(=O)CCC([O-])=O)C(=O)OCC
Purity: 98.0
Solubility: Soluble in DMSO (10 mg/mL) and in ethanol (5mg/mL).
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
AHU-377 hemicalcium salt is angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases. LBQ657 inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides that work mainly by reducing blood volume.
Size: 10mg solid,2mg solid 10mg solid,2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.