bs-6485C
[Life Science]
GSK-2981278
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 461.61
Formula: C25 H35 N O5 S
CAS Number: 1474110-21-8
InChi Key: LZLBRISQTJVZNP-UHFFFAOYSA-N
InChi: InChI=1S/C25H35NO5S/c1-4-20-5-7-23(8-6-20)26(16-19(2)3)32(28,29)24-9-10-25(22(15-24)17-27)31-18-21-11-13-30-14-12-21/h5-10,15,19,21,27H,4,11-14,16-18H2,1-3H3
Smiles: CC(C)CN(C1=CC=C(CC)C=C1)S(=O)(=O)C1=CC(CO)=C(C=C1)OCC1CCOCC1
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power
Shelf Life: 1.0 years
Formula: C25 H35 N O5 S
CAS Number: 1474110-21-8
InChi Key: LZLBRISQTJVZNP-UHFFFAOYSA-N
InChi: InChI=1S/C25H35NO5S/c1-4-20-5-7-23(8-6-20)26(16-19(2)3)32(28,29)24-9-10-25(22(15-24)17-27)31-18-21-11-13-30-14-12-21/h5-10,15,19,21,27H,4,11-14,16-18H2,1-3H3
Smiles: CC(C)CN(C1=CC=C(CC)C=C1)S(=O)(=O)C1=CC(CO)=C(C=C1)OCC1CCOCC1
Purity: 98.0
Solubility: Soluble in DMSO
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
GSK-2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma). GSK-2981278 is a strong RORĪ³-selective inverse agonist that inhibits activation of the il17 promoter. GSK-2981278 robustly inhibits RORĪ³-mediated cytokine production at both the mRNA and protein level. GSK-2981278 attenuates inflammation in a mouse model of psoriasis. Topical treatment with GSK-2981278 will significantly limit Th17-type cytokine expression and should therefore lead to improved clinical outcomes for patients.
Size: 10mg solid, 2mg solid 10mg solid, 2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.