bs-6483C
[Life Science]
CC-115
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 336.35
Formula: C16 H16 N8 O
CAS Number: 1228013-15-7
InChi Key: GMYLVKUGJMYTFB-UHFFFAOYSA-N
InChi: InChI=1S/C16H16N8O/c1-3-24-13(25)7-18-15-16(24)22-12(6-17-15)10-4-5-11(21-9(10)2)14-19-8-20-23-14/h4-6,8H,3,7H2,1-2H3,(H,17,18)(H,19,20,23)
Smiles: CC1=NC(=CC=C1C1=CN=C2NCC(=O)N(CC)C2=N1)C1NN=CN=1
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power
Shelf Life: 1.0 years
Formula: C16 H16 N8 O
CAS Number: 1228013-15-7
InChi Key: GMYLVKUGJMYTFB-UHFFFAOYSA-N
InChi: InChI=1S/C16H16N8O/c1-3-24-13(25)7-18-15-16(24)22-12(6-17-15)10-4-5-11(21-9(10)2)14-19-8-20-23-14/h4-6,8H,3,7H2,1-2H3,(H,17,18)(H,19,20,23)
Smiles: CC1=NC(=CC=C1C1=CN=C2NCC(=O)N(CC)C2=N1)C1NN=CN=1
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR), with potential antineoplastic activity. CC-115 binds to and inhibits the activity of DNA-PK and both raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2), which may lead to a reduction in cellular proliferation of cancer cells expressing DNA-PK and TOR. DNA-PK, a serine/threonine kinase and a member of the PI3K-related kinase subfamily of protein kinases, is activated upon DNA damage and plays a key role in repairing double-stranded DNA breaks via the DNA nonhomologous end joining (NHEJ) pathway.
Size: 10mg solid,2mg solid 10mg solid,2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.