bs-6418C
[Life Science]
Su-11274
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 568.09
Formula: C28 H30 Cl N5 O4 S
CAS Number: 658084-23-2
InChi Key: FPYJSJDOHRDAMT-KQWNVCNZSA-N
InChi: InChI=1S/C28H30ClN5O4S/c1-17-25(30-18(2)26(17)28(36)34-12-10-32(3)11-13-34)16-23-22-15-21(8-9-24(22)31-27(23)35)39(37,38)33(4)20-7-5-6-19(29)14-20/h5-9,14-16,30H,10-13H2,1-4H3,(H,31,35)/b23-16-
Smiles: CN1CCN(CC1)C(=O)C1C(C)=C(/C=C2/C3=CC(=CC=C3NC/2=O)S(=O)(=O)N(C)C2=CC(Cl)=CC=C2)NC=1C
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power
Shelf Life: 1.0 years
Formula: C28 H30 Cl N5 O4 S
CAS Number: 658084-23-2
InChi Key: FPYJSJDOHRDAMT-KQWNVCNZSA-N
InChi: InChI=1S/C28H30ClN5O4S/c1-17-25(30-18(2)26(17)28(36)34-12-10-32(3)11-13-34)16-23-22-15-21(8-9-24(22)31-27(23)35)39(37,38)33(4)20-7-5-6-19(29)14-20/h5-9,14-16,30H,10-13H2,1-4H3,(H,31,35)/b23-16-
Smiles: CN1CCN(CC1)C(=O)C1C(C)=C(/C=C2/C3=CC(=CC=C3NC/2=O)S(=O)(=O)N(C)C2=CC(Cl)=CC=C2)NC=1C
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
Su-11274 is a selective Met tyrosine kinase inhibitor with IC50 of 10 nM. Su-11274 increases tumorigenicity and enriched for melanoma-initiating cells by bioenergetic modulation. Su-11274 suppresses proliferation and motility of pancreatic cancer cells. Su-11274 enhances the response of the prostate cancer cell line DU145 to ionizing radiation. Su-11274 exhibits a selective inhibition pattern toward different receptor mutated variants.
Size: 10mg solid, 2mg solid 10mg solid, 2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.