bs-6416C
[Life Science]
JNK-IN-8
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 507.59
Formula: C29 H29 N7 O2
CAS Number: 1410880-22-6
InChi Key: GJFCSAPFHAXMSF-UXBLZVDNSA-N
InChi: InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+
Smiles: CC1C=C(C=CC=1NC1N=C(C=CN=1)C1C=NC=CC=1)NC(=O)C1=CC(=CC=C1)NC(=O)/C=C/CN(C)C
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power
Shelf Life: 1.0 years
Formula: C29 H29 N7 O2
CAS Number: 1410880-22-6
InChi Key: GJFCSAPFHAXMSF-UXBLZVDNSA-N
InChi: InChI=1S/C29H29N7O2/c1-20-17-24(11-12-25(20)34-29-31-15-13-26(35-29)22-8-5-14-30-19-22)33-28(38)21-7-4-9-23(18-21)32-27(37)10-6-16-36(2)3/h4-15,17-19H,16H2,1-3H3,(H,32,37)(H,33,38)(H,31,34,35)/b10-6+
Smiles: CC1C=C(C=CC=1NC1N=C(C=CN=1)C1C=NC=CC=1)NC(=O)C1=CC(=CC=C1)NC(=O)/C=C/CN(C)C
Purity: 98.0
Solubility: Soluble in DMSO, not in water
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
JNK-IN-8, also known as JNK Inhibitor XVI, is a selective JNK inhibitor that inhibits phosphorylation of c-Jun, a direct substrate of JNK, in cells exposed to submicromolar drug in a manner that depends on covalent modification of the conserved cysteine residue. Extensive biochemical, cellular, and pathway-based profiling establish the selectivity of JNK-IN-8 for JNK and suggests that the compound will be broadly useful as a pharmacological probe of JNK-dependent signal transduction.
Size: 10mg solid,2mg solid 10mg solid,2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.