DATASHEET
Formulation
Powder
Storage:
Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 419.52
Formula: C25 H29 N3 O3
CAS Number: 1627503-67-6
InChi Key: BHUXVRVMMYAXKN-UHFFFAOYSA-N
InChi: InChI=1S/C25H29N3O3/c1-17-22(19-14-23(29-2)25(31-4)24(15-19)30-3)13-20(16-27-17)18-5-7-21(8-6-18)28-11-9-26-10-12-28/h5-8,13-16,26H,9-12H2,1-4H3
Smiles: CC1N=CC(=CC=1C1=CC(OC)=C(OC)C(=C1)OC)C1C=CC(=CC=1)N1CCNCC1
Purity: 98.0
Solubility: DMSO : ≥ 100 mg/mL (238.37 mM)
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
LDN-214117 is a selective and potent ALK2 inhibitor. LDN-214117 inhibited ALK2 most, with a biochemical IC50 of 24 nM. There are currently no effective therapies for fibrodysplasia ossificans progressiva (FOP), a debilitating and progressive heterotopic ossification disease caused by activating mutations of ACVR1 encoding the BMP type I receptor kinase ALK2. LDN-214117 shows a high degree of selectivity for ALK2 and low cytotoxicity that could provide a template for preclinical development.