bs-6400C
[Life Science]
AG-1517
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 360.21
Formula: C16 H14 Br N3 O2
CAS Number: 153436-54-5
InChi Key: LSPANGZZENHZNJ-UHFFFAOYSA-N
InChi: InChI=1S/C16H14BrN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
Smiles: COC1C=C2C(NC3=CC(Br)=CC=C3)=NC=NC2=CC=1OC
Purity: 98.0
Solubility: Soluble in DMSO, not soluble in water.
Appearance: Solid Power
Shelf Life: 1.0 years
Formula: C16 H14 Br N3 O2
CAS Number: 153436-54-5
InChi Key: LSPANGZZENHZNJ-UHFFFAOYSA-N
InChi: InChI=1S/C16H14BrN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
Smiles: COC1C=C2C(NC3=CC(Br)=CC=C3)=NC=NC2=CC=1OC
Purity: 98.0
Solubility: Soluble in DMSO, not soluble in water.
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
AG-1517 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also upregulates the expression of the tumor suppressor retinoic acid receptor-beta 2 (RAR-beta2).
Size: 10mg solid, 2mg solid 10mg solid, 2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.