bs-60430C
[Life Science]
BIX-02188
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 412.48
Formula: C25 H24 N4 O2
CAS Number: 334949-59-6
InChi Key: FSZPIAXLCCQFCM-FCQUAONHSA-N
InChi: InChI=1S/C25H24N4O2/c1-29(2)15-16-7-6-10-19(13-16)27-23(17-8-4-3-5-9-17)22-20-12-11-18(24(26)30)14-21(20)28-25(22)31/h3-14,27H,15H2,1-2H3,(H2,26,30)(H,28,31)/b23-22-
Smiles: CN(C)CC1C=C(C=CC=1)N/C(=C1/C2=CC=C(C=C2NC/1=O)C(N)=O)/C1C=CC=CC=1
Purity: 98.0
Solubility: DMSO: ≥ 45 mg/mL
Appearance: Solid Power
Shelf Life: 1.0 years
Formula: C25 H24 N4 O2
CAS Number: 334949-59-6
InChi Key: FSZPIAXLCCQFCM-FCQUAONHSA-N
InChi: InChI=1S/C25H24N4O2/c1-29(2)15-16-7-6-10-19(13-16)27-23(17-8-4-3-5-9-17)22-20-12-11-18(24(26)30)14-21(20)28-25(22)31/h3-14,27H,15H2,1-2H3,(H2,26,30)(H,28,31)/b23-22-
Smiles: CN(C)CC1C=C(C=CC=1)N/C(=C1/C2=CC=C(C=C2NC/1=O)C(N)=O)/C1C=CC=CC=1
Purity: 98.0
Solubility: DMSO: ≥ 45 mg/mL
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
BIX-02188 is a potent inhibitor of MEK5 (IC50 = 4.3 nM) with reduced activity towards inhibition of ERK5 and TGFβR1 (IC50s = 810 and 1, 800 nM, respectively). Inhibition of MEK5 by BIX-02188 induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD.
Size: 2 mg solid, 10 mg solid 2 mg solid, 10 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.