bs-60428C
[Life Science]
Crenolanib
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 443.54
Formula: C26 H29 N5 O2
CAS Number: 670220-88-9
InChi Key: DYNHJHQFHQTFTP-UHFFFAOYSA-N
InChi: InChI=1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3
Smiles: CC1(COC2C=C3N=CN(C4=CC=C5C=CC=C(C5=N4)N4CCC(N)CC4)C3=CC=2)COC1
Purity: 98.0
Solubility: 10 mM in DMSO
Appearance: Solid Power
Shelf Life: 1.0 years
Formula: C26 H29 N5 O2
CAS Number: 670220-88-9
InChi Key: DYNHJHQFHQTFTP-UHFFFAOYSA-N
InChi: InChI=1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3
Smiles: CC1(COC2C=C3N=CN(C4=CC=C5C=CC=C(C5=N4)N4CCC(N)CC4)C3=CC=2)COC1
Purity: 98.0
Solubility: 10 mM in DMSO
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
Crenolanib is a potent and selective inhibitor of PDGFRα/β, FLT3 with Kd of 2.1 nM/3.2 nM, 0.74 nM, respectively, sensitive to D842V mutation not V561D mutation, and > 100-fold more selective for PDGFR than c-Kit, VEGFR-2, TIE-2, FGFR-2, EGFR, erbB2, and Src.
Size: 10mg solid, 2 mg solid10mg solid, 2 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.