bs-60422C
[Life Science]
U0126-EtOH
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 426.56
Formula: C20 H22 N6 O S2
CAS Number: 1173097-76-1
InChi Key: CFQULUVMLGZVAF-OYJDLGDISA-N
InChi: InChI=1S/C18H16N6S2.C2H6O/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22;1-2-3/h1-8H,21-24H2;3H,2H2,1H3/b17-11+,18-12+;
Smiles: CCO.NC1=CC=CC=C1SC(N)=C(C#N)C(C#N)=C(N)SC1=CC=CC=C1N
Purity: 98.0
Solubility: DMSO: ≥ 49 mg/mL
Appearance: Solid Power
Shelf Life: 1.0 years
Formula: C20 H22 N6 O S2
CAS Number: 1173097-76-1
InChi Key: CFQULUVMLGZVAF-OYJDLGDISA-N
InChi: InChI=1S/C18H16N6S2.C2H6O/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22;1-2-3/h1-8H,21-24H2;3H,2H2,1H3/b17-11+,18-12+;
Smiles: CCO.NC1=CC=CC=C1SC(N)=C(C#N)C(C#N)=C(N)SC1=CC=CC=C1N
Purity: 98.0
Solubility: DMSO: ≥ 49 mg/mL
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 μM/0.06 μM, 100-fold higher affinity for ΔN3-S218E/S222D MEK than PD98059. This inhibition of MEK1/2 is noncompetitive with ERK and ATP.
Size: 2 mg solid, 10mg solid2 mg solid, 10mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.