DATASHEET
Formulation
Powder
Storage:
Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 273.23
Formula: C11 H6 F3 N O2 S
CAS Number: 438190-29-5
InChi Key: NGJLOFCOEOHFKQ-VMPITWQZSA-N
InChi: InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5+
Smiles: O=C1NC(=O)SC1=CC1=CC(=CC=C1)C(F)(F)F
Purity: 98.0
Solubility: 10 mM in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
SMI-4a is a potent and selective Pim protein kinase inhibitor, which blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma. SMI-4a was found to induce phosphorylation of extracellular signal-related kinase1/2 (ERK1/2), and the combination of SMI-4a and a mitogen-activated protein kinase kinase 1/2 (MEK1/2) inhibitor was highly synergistic in killing pre-T-LBL cells. SMI-4a may be developed as a therapeutic strategy for the treatment of pre-T-LBL.