bs-60415C
[Life Science]
RKI-1447
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 326.37
Formula: C16 H14 N4 O2 S
CAS Number: 1342278-01-6
InChi Key: GDVRVPIXWXOKQO-UHFFFAOYSA-N
InChi: InChI=1S/C16H14N4O2S/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12/h1-8,10,21H,9H2,(H2,18,19,20,22)
Smiles: OC1C=C(CNC(=O)NC2=NC(=CS2)C2C=CN=CC=2)C=CC=1
Purity: 98.0
Solubility: 10 mM in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C16 H14 N4 O2 S
CAS Number: 1342278-01-6
InChi Key: GDVRVPIXWXOKQO-UHFFFAOYSA-N
InChi: InChI=1S/C16H14N4O2S/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12/h1-8,10,21H,9H2,(H2,18,19,20,22)
Smiles: OC1C=C(CNC(=O)NC2=NC(=CS2)C2C=CN=CC=2)C=CC=1
Purity: 98.0
Solubility: 10 mM in DMSO
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. RKI-1447 is a Type I kinase inhibitor that binds the ATP binding site through interactions with the hinge region and the DFG motif. RKI-1447 suppressed phosphorylation of the ROCK substrates MLC-2 and MYPT-1 in human cancer cells.
Size: 10mg solid, 2 mg solid10mg solid, 2 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.