DATASHEET
Formulation
Powder
Storage:
Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 291.3
Formula: C17 H13 N3 O2
CAS Number: 796-42-9
InChi Key: WQSHHAVECQJKLX-YBFXNURJSA-N
InChi: InChI=1S/C17H13N3O2/c21-16-6-5-12-3-1-2-4-14(12)15(16)11-19-20-17(22)13-7-9-18-10-8-13/h1-11,21H,(H,20,22)/b19-11+
Smiles: OC1C=CC2=CC=CC=C2C=1C=NNC(=O)C1C=CN=CC=1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
AS8351 is a potent iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B) by competing with a-ketoglutarate. KDM5B a histone H3K4 demethylase involved in regulation of cell proliferation and stem cell self-renewal and differentiation. It can induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR99021, A83-01, BIX01294, SC1, Y-27632, OAC2, SU16f and JNJ10198409.