DATASHEET
Formulation
Powder
Storage:
Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 321.37
Formula: C19 H19 N3 O2
CAS Number: 1445251-22-8
InChi Key: QIHBWVVVRYYYRO-ZDUSSCGKSA-N
InChi: InChI=1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)20-18(23)12-11-17-21-16-10-6-5-9-15(16)19(24)22-17/h2-10,13H,11-12H2,1H3,(H,20,23)(H,21,22,24)/t13-/m0/s1
Smiles: C[C@H](NC(=O)CCC1NC(=O)C2=CC=CC=C2N=1)C1C=CC=CC=1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
ME0328 is a potent, selective and cell permeable PARP-3 inhibitor with IC50 of 0.89 μM. It has good selectivity against PARP-1, PARP-2 and other ARDT enzymes. Enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells.