bs-60325C
[Life Science]
GN44028 --- HIF-1α Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 305.33
Formula: C18 H15 N3 O2
CAS Number: 1421448-26-1
InChi Key: CGZKSZVSWAAUHE-UHFFFAOYSA-N
InChi: InChI=1S/C18H15N3O2/c1-2-4-13-11(3-1)9-14-17(13)20-21-18(14)19-12-5-6-15-16(10-12)23-8-7-22-15/h1-6,10H,7-9H2,(H2,19,20,21)
Smiles: C1C2C(NC3=CC4OCCOC=4C=C3)=NNC=2C2=CC=CC=C21
Purity: 98.0
Solubility: DMSO up to 100 mM; EtOH up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C18 H15 N3 O2
CAS Number: 1421448-26-1
InChi Key: CGZKSZVSWAAUHE-UHFFFAOYSA-N
InChi: InChI=1S/C18H15N3O2/c1-2-4-13-11(3-1)9-14-17(13)20-21-18(14)19-12-5-6-15-16(10-12)23-8-7-22-15/h1-6,10H,7-9H2,(H2,19,20,21)
Smiles: C1C2C(NC3=CC4OCCOC=4C=C3)=NNC=2C2=CC=CC=C21
Purity: 98.0
Solubility: DMSO up to 100 mM; EtOH up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
GN44028 is potent and selective HIF-1α inhibitor with IC50 ~14 nM. It inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization in nuclei under the hypoxic conditions. This suggests that GN44028 probably affected the transcriptional pathway induced by the HIF-1α/HIF-1β heterodimer.
Size: 2 mg solid,10 mg solid 2 mg solid,10 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.