bs-60324C
[Life Science]
(Z)-4-Hydroxytamoxifen --- CRISPR Editing Enhancer
DATASHEET
Formulation Powder
Storage: Powder: 4C for 1 year, -20C for 3 years. DMSO: 4C for 3 month.
Product Information:
Molecular Weight: 387.51
Formula: C26 H29 N O2
CAS Number: 68047-06-3
InChi Key: TXUZVZSFRXZGTL-QPLCGJKRSA-N
InChi: InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
Smiles: CC/C(=C(\C1C=CC(O)=CC=1)/C1C=CC(=CC=1)OCCN(C)C)/C1C=CC=CC=1
Purity: 98.0
Solubility: DMSO up to 100 mM; EtOH up to 50 mM
Appearance: Solid powder
Shelf Life: 1.0 years
Formula: C26 H29 N O2
CAS Number: 68047-06-3
InChi Key: TXUZVZSFRXZGTL-QPLCGJKRSA-N
InChi: InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
Smiles: CC/C(=C(\C1C=CC(O)=CC=1)/C1C=CC(=CC=1)OCCN(C)C)/C1C=CC=CC=1
Purity: 98.0
Solubility: DMSO up to 100 mM; EtOH up to 50 mM
Appearance: Solid powder
Shelf Life: 1.0 years
Description:
(Z)-4-Hydroxytamoxifen (also called 4-OH-TAM) was previously characterized as an Estrogen Receptor antagonist and now found to improve genome-editing specificity in CRISPR-mediated gene editing. It can activate intein-linked inactive Cas9, reducing off-target. Such system has ~25-fold higher specificity than wtCas9. (Z)-4-Hydroxytamoxifen is a Tamoxifen metabolite to be used as chemotherapeutic agent. It exhibits greater potency than Tamoxifen.
Size: 10mg,2mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.