bs-60321C
[Life Science]
GSK591 (EPZ015866), PRMT5 Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 380.48
Formula: C22 H28 N4 O2
CAS Number: 1616391-87-7
InChi Key: TWKYXZSXXXKKJU-FQEVSTJZSA-N
InChi: InChI=1S/C22H28N4O2/c27-20(15-26-11-9-16-4-1-2-5-18(16)14-26)13-24-22(28)17-8-10-23-21(12-17)25-19-6-3-7-19/h1-2,4-5,8,10,12,19-20,27H,3,6-7,9,11,13-15H2,(H,23,25)(H,24,28)/t20-/m0/s1
Smiles: O[C@@H](CNC(=O)C1=CC(NC2CCC2)=NC=C1)CN1CCC2=CC=CC=C2C1
Purity: 98.0
Solubility: DMSO: 76 mg/mL(199.74 mM). Water: Insoluble.
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C22 H28 N4 O2
CAS Number: 1616391-87-7
InChi Key: TWKYXZSXXXKKJU-FQEVSTJZSA-N
InChi: InChI=1S/C22H28N4O2/c27-20(15-26-11-9-16-4-1-2-5-18(16)14-26)13-24-22(28)17-8-10-23-21(12-17)25-19-6-3-7-19/h1-2,4-5,8,10,12,19-20,27H,3,6-7,9,11,13-15H2,(H,23,25)(H,24,28)/t20-/m0/s1
Smiles: O[C@@H](CNC(=O)C1=CC(NC2CCC2)=NC=C1)CN1CCC2=CC=CC=C2C1
Purity: 98.0
Solubility: DMSO: 76 mg/mL(199.74 mM). Water: Insoluble.
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
GSK591, also known as EPZ015866 and GSK3203591, is a chemical probe for PRMT5. In an in vitro biochemical assay, GSK591 potently inhibits the PRMT5/MEP50 complex from methylating (histone) H4 with IC50 = 11 nM. In Z-138 cells, GSK591 inhibits the symmetric arginine methylation of SmD3 with EC50 = 56 nM. Further, GSK591 is selective for PRMT5 (up to 50 micromolar) relative to a panel of methyltransferases.
Size: 10mg solid, 2 mg solid10mg solid, 2 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.