bs-60320C
[Life Science]
HLCL-61, PRMT5 Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 380.91
Formula: C23 H25 Cl N2 O
CAS Number: 1158279-20-9
InChi Key: XYAVCNMZZKTEGR-UHFFFAOYSA-N
InChi: InChI=1S/C23H24N2O.ClH/c1-3-25-21-10-6-5-9-19(21)20-14-17(12-13-22(20)25)15-24-16-18-8-4-7-11-23(18)26-2;/h4-14,24H,3,15-16H2,1-2H3;1H
Smiles: Cl.CCN1C2=CC=CC=C2C2C=C(CNCC3C=CC=CC=3OC)C=CC1=2
Purity: 98.0
Solubility: DMSO and EtOH up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C23 H25 Cl N2 O
CAS Number: 1158279-20-9
InChi Key: XYAVCNMZZKTEGR-UHFFFAOYSA-N
InChi: InChI=1S/C23H24N2O.ClH/c1-3-25-21-10-6-5-9-19(21)20-14-17(12-13-22(20)25)15-24-16-18-8-4-7-11-23(18)26-2;/h4-14,24H,3,15-16H2,1-2H3;1H
Smiles: Cl.CCN1C2=CC=CC=C2C2C=C(CNCC3C=CC=CC=3OC)C=CC1=2
Purity: 98.0
Solubility: DMSO and EtOH up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
HLCL-61 is a potent and selective Protein arginine methyltransferase-5 (PRMT5) Inhibitor. It shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members. HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples.Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also results in a decrease of cell viability. HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h.
Size: 2 mg solid,10 mg solid 2 mg solid,10 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.