bs-60312C
[Life Science]
PD-1/PD-L1 Inhibitor C1
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 475.58
Formula: C29 H33 N O5
CAS Number: 1675201-83-8
InChi Key: ZBOYJODMIAUJHH-SANMLTNESA-N
InChi: InChI=1S/C29H33NO5/c1-20-22(12-9-13-24(20)21-10-5-4-6-11-21)19-35-23-16-27(33-2)25(28(17-23)34-3)18-30-15-8-7-14-26(30)29(31)32/h4-6,9-13,16-17,26H,7-8,14-15,18-19H2,1-3H3,(H,31,32)/t26-/m0/s1
Smiles: CC1C(COC2=CC(OC)=C(CN3CCCC[C@H]3C(O)=O)C(=C2)OC)=CC=CC=1C1C=CC=CC=1
Purity: 98.0
Solubility: DMSO up to 100 mM; Water up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C29 H33 N O5
CAS Number: 1675201-83-8
InChi Key: ZBOYJODMIAUJHH-SANMLTNESA-N
InChi: InChI=1S/C29H33NO5/c1-20-22(12-9-13-24(20)21-10-5-4-6-11-21)19-35-23-16-27(33-2)25(28(17-23)34-3)18-30-15-8-7-14-26(30)29(31)32/h4-6,9-13,16-17,26H,7-8,14-15,18-19H2,1-3H3,(H,31,32)/t26-/m0/s1
Smiles: CC1C(COC2=CC(OC)=C(CN3CCCC[C@H]3C(O)=O)C(=C2)OC)=CC=CC=1C1C=CC=CC=1
Purity: 98.0
Solubility: DMSO up to 100 mM; Water up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
PD-1/PD-L1 inhibitor C1 is a potent and selective small molecule inhibitor of the PD-1/PD-L1 protein/protein interactions with IC50 < 100 nM (PD-1/PD-L1 Homogenous Time-Resolved Fluorescence (HTRF) binding assay). It may potentially be useful in the treatment of cancer as well as infectious diseases such as hepatitis C. The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis.
Size: 2 mg solid, 10 mg solid 2 mg solid, 10 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.