bs-60309C
[Life Science]
BAY11-7082, E2 Ubiquitin Conjugating Enzyme Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 207.25
Formula: C10 H9 N O2 S
CAS Number: 19542-67-7
InChi Key: DOEWDSDBFRHVAP-KRXBUXKQSA-N
InChi: InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
Smiles: CC1=CC=C(C=C1)S(=O)(=O)/C=C/C#N
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C10 H9 N O2 S
CAS Number: 19542-67-7
InChi Key: DOEWDSDBFRHVAP-KRXBUXKQSA-N
InChi: InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
Smiles: CC1=CC=C(C=C1)S(=O)(=O)/C=C/C#N
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
BAY11-7082 is a potent and selective E2 ubiquitin (Ub) conjugating enzyme inhibitor. It inhibits the conjugation of Ub to a range of E2 enzymes and inhibits E2 enzyme mediated IκBα phosphorylation and indirectly decreases NF-κb activity. BAY11-7082 also reversibly activates MAPK signaling and induces apoptosis of leukemic T cell and B-cell lymphoma cell lines.
Size: 2 mg solid, 10mg solid2 mg solid, 10mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.