bs-60308C
[Life Science]
GS143, IkappaB Ubiquitination Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 466.46
Formula: C28 H19 F N2 O4
CAS Number: 916232-21-8
InChi Key: IZPMWFSVTDOCDI-HAVVHWLPSA-N
InChi: InChI=1S/C28H19FN2O4/c29-24-9-5-4-8-22(24)26-15-14-21(35-26)17-23-25(16-18-6-2-1-3-7-18)30-31(27(23)32)20-12-10-19(11-13-20)28(33)34/h1-15,17H,16H2,(H,33,34)/b23-17+
Smiles: OC(=O)C1C=CC(=CC=1)N1N=C(CC2C=CC=CC=2)C(=CC2=CC=C(O2)C2C=CC=CC=2F)C1=O
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C28 H19 F N2 O4
CAS Number: 916232-21-8
InChi Key: IZPMWFSVTDOCDI-HAVVHWLPSA-N
InChi: InChI=1S/C28H19FN2O4/c29-24-9-5-4-8-22(24)26-15-14-21(35-26)17-23-25(16-18-6-2-1-3-7-18)30-31(27(23)32)20-12-10-19(11-13-20)28(33)34/h1-15,17H,16H2,(H,33,34)/b23-17+
Smiles: OC(=O)C1C=CC(=CC=1)N1N=C(CC2C=CC=CC=2)C(=CC2=CC=C(O2)C2C=CC=CC=2F)C1=O
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
GS143 is selective β-TrCP1 ligase inhibitor, inhibits IκBα ubiquitination with IC50 ~5.2 μM without affecting proteasome activity. It blocks LPS-induced expression of inflammatory cytokines in human myelomonocytic cells. It suppresses antigen-induced NFκB expression, inflammation and mucus production in airways of OVA-sensitized mice.
Size: 10mg solid, 2 mg solid10mg solid, 2 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.