bs-60304C
[Life Science]
TEPP-46 (ML265), Pyruvate Kinase M2 (PKM2) Activator
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 372.46
Formula: C17 H16 N4 O2 S2
CAS Number: 1221186-53-3
InChi Key: ZWKJWVSEDISQIS-UHFFFAOYSA-N
InChi: InChI=1S/C17H16N4O2S2/c1-20-13-7-14(25(2)23)24-16(13)12-8-19-21(17(22)15(12)20)9-10-4-3-5-11(18)6-10/h3-8H,9,18H2,1-2H3
Smiles: CN1C2=C(C=NN(CC3=CC(N)=CC=C3)C2=O)C2SC(=CC1=2)S(C)=O
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C17 H16 N4 O2 S2
CAS Number: 1221186-53-3
InChi Key: ZWKJWVSEDISQIS-UHFFFAOYSA-N
InChi: InChI=1S/C17H16N4O2S2/c1-20-13-7-14(25(2)23)24-16(13)12-8-19-21(17(22)15(12)20)9-10-4-3-5-11(18)6-10/h3-8H,9,18H2,1-2H3
Smiles: CN1C2=C(C=NN(CC3=CC(N)=CC=C3)C2=O)C2SC(=CC1=2)S(C)=O
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
TEPP-46 (ML265) is a potent and selective Pyruvate kinase M2 (PKM2) activator with EC50 ~92 nM. It demonstrates >100-fold selectivity for PKM2 over the related PKM1, PKR, and PKL isoforms. It can stabilize pyruvate kinase subunit interactions, promote PKM2 tetramer formation and prevent inhibition by phosphotyrosine signaling. It can alter metabolism in cultured cells, and inhibit xenograft tumor growth in vivo. TEPP-46 inhibits LPS-induced Hif-1α and IL-1β, as well as the expression of a range of other Hif-1α-dependent genes.
Size: 2 mg solid, 10mg solid2 mg solid, 10mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.