bs-60300C

DATASHEET

Formulation Powder

Storage: Store in dry, dark place at -20C for 1 year.

Product Information:

Molecular Weight: 524.23

Formula: C20 H16 Br2 N2 O3 S

CAS Number: 312756-74-4

InChi Key: SWKAVEUTKGKHSR-UHFFFAOYSA-N

InChi: InChI=1S/C20H16Br2N2O3S/c21-16-7-9-17(10-8-16)24-20(25)15-6-11-18(22)19(12-15)28(26,27)23-13-14-4-2-1-3-5-14/h1-12,23H,13H2,(H,24,25)

Smiles: O=C(NC1C=CC(Br)=CC=1)C1C=CC(Br)=C(C=1)S(=O)(=O)NCC1C=CC=CC=1

Purity: 98.0

Solubility: DMSO up to 100 mM

Appearance: Solid Power

Shelf Life: 1.0 years

Description:

RS-1 was previously characterized as a RAD51-Stimulatory compound and now found to be an HDR enhancer to enhance CRISPR/Cas9- and TALEN-mediated knock-in efficiency. It increases the knock-in efficiency by two- to five-fold at different loci, whereas NHEJ inhibitor SCR7 has minimal effects. RS-1 was applied for animal production and have achieved multifold improvement on the knock-in rates as well. RS-1 can stimulate the human homologous recombination protein RAD51in various conditions. In PC3 prostate cancer cells, RS-1–induced lethality was accompanied by the formation of microscopically visible RAD51 nuclear protein foci occurring in the absence of any DNA-damaging treatment. Treatment with RS-1 promoted significant antitumor responses in a mouse model.