bs-60295C
[Life Science]
ORY-1001 (RG-6016), LSD1 Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 303.27
Formula: C15 H24 Cl2 N2
CAS Number: 1431326-61-2
InChi Key: UCINOBZMLCREGM-RNNUGBGQSA-N
InChi: InChI=1S/C15H22N2.2ClH/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11;;/h1-5,12-15,17H,6-10,16H2;2*1H/t12?,13?,14-,15+;;/m0../s1
Smiles: Cl.Cl.NC1CCC(CC1)N[C@@H]1C[C@H]1C1C=CC=CC=1
Purity: 98.0
Solubility: DMSO up to 15 mM; Water up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C15 H24 Cl2 N2
CAS Number: 1431326-61-2
InChi Key: UCINOBZMLCREGM-RNNUGBGQSA-N
InChi: InChI=1S/C15H22N2.2ClH/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11;;/h1-5,12-15,17H,6-10,16H2;2*1H/t12?,13?,14-,15+;;/m0../s1
Smiles: Cl.Cl.NC1CCC(CC1)N[C@@H]1C[C@H]1C1C=CC=CC=1
Purity: 98.0
Solubility: DMSO up to 15 mM; Water up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
ORY-1001 is a highly potent and selective inhibitor of Lysine Specific Demethylase 1 (LSD1) with IC50 <20 nM. It is highly selective over related enzymes such as MAO-A/B. ORY-1001 affects AML stem cells, a sub-population of cancer cells that has been proposed to be responsible for frequent relapses of the disease. It significantly reduces tumor cell load and increases survival time in mouse models of Acute Lymphoblastic Leukaemia. Currently ORY-1001 is in Phase I/IIA clinical trial for acute leukemia.
Size: 10mg solid, 2 mg solid10mg solid, 2 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.