bs-60292C
[Life Science]
INCB024360 (Epacadostat), IDO Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 438.23
Formula: C11 H13 Br F N7 O4 S
CAS Number: 1204669-58-8
InChi Key: FBKMWOJEPMPVTQ-UHFFFAOYSA-N
InChi: InChI=1S/C11H13BrFN7O4S/c12-7-5-6(1-2-8(7)13)17-11(18-21)9-10(20-24-19-9)15-3-4-16-25(14,22)23/h1-2,5,16,21H,3-4H2,(H,15,20)(H,17,18)(H2,14,22,23)
Smiles: NS(=O)(=O)NCCNC1=NON=C1/C(/NC1=CC(Br)=C(F)C=C1)=N/O
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C11 H13 Br F N7 O4 S
CAS Number: 1204669-58-8
InChi Key: FBKMWOJEPMPVTQ-UHFFFAOYSA-N
InChi: InChI=1S/C11H13BrFN7O4S/c12-7-5-6(1-2-8(7)13)17-11(18-21)9-10(20-24-19-9)15-3-4-16-25(14,22)23/h1-2,5,16,21H,3-4H2,(H,15,20)(H,17,18)(H2,14,22,23)
Smiles: NS(=O)(=O)NCCNC1=NON=C1/C(/NC1=CC(Br)=C(F)C=C1)=N/O
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
INCB024360 is a potent and selective indoleamine 2, 3-dioxygenase (IDO1) inhibitor with IC50 ~10 nM It displays high selectivity over other related enzymes such as IDO2 or tryptophan 2, 3-dioxygenase (TDO). In coculture systems of human allogeneic lymphocytes with dendritic cells (DCs) or tumor cells, INCB024360 inhibition of IDO1 promotes T and natural killer (NK)-cell growth, increases IFN-gamma production, and reduces conversion to regulatory T (T(reg))-like cells. Administration of INCB024360 to tumor-bearing mice significantly inhibits tumor growth in a lymphocyte-dependent manner. INCB024360 has completed Phase I clinical trials and is now being used in combination with other cancer immunotherapy agents.
Size: 2 mg solid,10 mg solid 2 mg solid,10 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.