bs-60290C
[Life Science]
NSC636819, KDM4A/KDM4B Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 510.15
Formula: C22 H12 Cl4 N2 O4
CAS Number: 1618672-71-1
InChi Key: YYZPXBXVBQSBDG-IJIVKGSJSA-N
InChi: InChI=1S/C22H12Cl4N2O4/c23-17-7-3-13(9-19(17)25)1-5-15-11-16(22(28(31)32)12-21(15)27(29)30)6-2-14-4-8-18(24)20(26)10-14/h1-12H/b5-1+,6-2+
Smiles: [O-][N+](=O)C1C=C(C(=CC=1/C=C/C1=CC(Cl)=C(Cl)C=C1)/C=C/C1=CC(Cl)=C(Cl)C=C1)[N+]([O-])=O
Purity: 98.0
Solubility: DMSO up to 10 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C22 H12 Cl4 N2 O4
CAS Number: 1618672-71-1
InChi Key: YYZPXBXVBQSBDG-IJIVKGSJSA-N
InChi: InChI=1S/C22H12Cl4N2O4/c23-17-7-3-13(9-19(17)25)1-5-15-11-16(22(28(31)32)12-21(15)27(29)30)6-2-14-4-8-18(24)20(26)10-14/h1-12H/b5-1+,6-2+
Smiles: [O-][N+](=O)C1C=C(C(=CC=1/C=C/C1=CC(Cl)=C(Cl)C=C1)/C=C/C1=CC(Cl)=C(Cl)C=C1)[N+]([O-])=O
Purity: 98.0
Solubility: DMSO up to 10 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
NSC636819 is a cell permeable and selective novel active-site KDM4A/KDM4B inhibitor with IC50 ~6.4 μM for KDM4A and 9.3 μM for KDM4B. It inhibits histone demethylase activity on H3K9me3 and induces apoptosis in LNCaP prostate cancer cells in vitro. It also negatively regulates androgen-responsive genes. The overexpression of KDM4A/KDM4B in prostate cancer and their association with androgen receptor suggest that KDM4A/KDM4B are potential progression factors for prostate cancer.
Size: 2 mg solid,10 mg solid 2 mg solid,10 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.