bs-60282C
[Life Science]
ML239, Breast Cancer Stem Cell Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 346.6
Formula: C13 H10 Cl3 N3 O2
CAS Number: 1378872-36-6
InChi Key: NVEDPFICKAIHKD-NGYBGAFCSA-N
InChi: InChI=1S/C13H10Cl3N3O2/c14-8-4-10(15)13(11(16)5-8)21-7-12(20)19-18-6-9-2-1-3-17-9/h1-6,17H,7H2,(H,19,20)/b18-6+
Smiles: O=C(COC1C(Cl)=CC(Cl)=CC=1Cl)N/N=C/C1=CC=CN1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C13 H10 Cl3 N3 O2
CAS Number: 1378872-36-6
InChi Key: NVEDPFICKAIHKD-NGYBGAFCSA-N
InChi: InChI=1S/C13H10Cl3N3O2/c14-8-4-10(15)13(11(16)5-8)21-7-12(20)19-18-6-9-2-1-3-17-9/h1-6,17H,7H2,(H,19,20)/b18-6+
Smiles: O=C(COC1C(Cl)=CC(Cl)=CC=1Cl)N/N=C/C1=CC=CN1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
ML239 is a potent and selective breast cancer stem cell inhibitor with IC50 ~1.16 μM. It displayed greater than 23-fold selective inhibition of the breast CSC-like cell line (HMLE_sh_Ecad) over the isogenic control cell line (HMLE_sh_GFP). It did not significantly inhibit tumorsphere formation in the breast cancer cell line SUM159, which is a mixture of CSCs and differentiated cells. ML239 is also cytotoxic towards MDA-MB-231 breast cancer cells.
Size: 2 mg solid, 10mg solid2 mg solid, 10mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.