bs-60281C
[Life Science]
GNF-7, Ras Signaling Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 547.53
Formula: C28 H24 F3 N7 O2
CAS Number: 839706-07-9
InChi Key: SZNYUUZOQHNEKB-UHFFFAOYSA-N
InChi: InChI=1S/C28H24F3N7O2/c1-16-7-9-21(34-25(39)18-5-4-6-20(11-18)28(29,30)31)12-23(16)38-15-19-13-33-26(36-24(19)37(3)27(38)40)35-22-10-8-17(2)32-14-22/h4-14H,15H2,1-3H3,(H,34,39)(H,33,35,36)
Smiles: CN1C2=NC(NC3=CC=C(C)N=C3)=NC=C2CN(C1=O)C1C=C(C=CC=1C)NC(=O)C1C=CC=C(C=1)C(F)(F)F
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C28 H24 F3 N7 O2
CAS Number: 839706-07-9
InChi Key: SZNYUUZOQHNEKB-UHFFFAOYSA-N
InChi: InChI=1S/C28H24F3N7O2/c1-16-7-9-21(34-25(39)18-5-4-6-20(11-18)28(29,30)31)12-23(16)38-15-19-13-33-26(36-24(19)37(3)27(38)40)35-22-10-8-17(2)32-14-22/h4-14H,15H2,1-3H3,(H,34,39)(H,33,35,36)
Smiles: CN1C2=NC(NC3=CC=C(C)N=C3)=NC=C2CN(C1=O)C1C=C(C=CC=1C)NC(=O)C1C=CC=C(C=1)C(F)(F)F
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
GNF-7 is a potent, selective and bioavailable Ras signaling inhibitor. It inhibits Ack1 and germinal center kinase (GCK). It can suppress proliferation, and induce cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. In vivo GNF-7 showed good efficacy in a xenotransplantation model and activity against primary AML patient samples.
Size: 10mg solid, 2 mg solid10mg solid, 2 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.