bs-60278C
[Life Science]
UF010, HDAC Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 271.15
Formula: C11 H15 Br N2 O
CAS Number: 537672-41-6
InChi Key: BVQCFCYPFJOOAV-UHFFFAOYSA-N
InChi: InChI=1S/C11H15BrN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
Smiles: CCCCNNC(=O)C1C=CC(Br)=CC=1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C11 H15 Br N2 O
CAS Number: 537672-41-6
InChi Key: BVQCFCYPFJOOAV-UHFFFAOYSA-N
InChi: InChI=1S/C11H15BrN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
Smiles: CCCCNNC(=O)C1C=CC(Br)=CC=1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
UF-010 is a Class I HDAC inhibitor (IC50 values are 0.06, 0.1, 0.5 and 1.5 μM for HDACs 3, 2, 1 and 8, respectively). UF010 inhibits cancer cell proliferation via class I HDAC inhibition. This causes global changes in protein acetylation and gene expression, resulting in activation of tumor suppressor pathways and concurrent inhibition of several oncogenic pathways. The isotype selectivity coupled with interesting biological activities in suppressing tumor cell proliferation support further preclinical development of the UF010 class of compounds for potential therapeutic applications.
Size: 2 mg solid, 10mg solid2 mg solid, 10mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.