bs-60269C
[Life Science]
FASCIN-G2, Fascin Inhibitor
DATASHEET
Formulation Powder
Storage: Powder: 4C for 1 year.
Product Information:
Molecular Weight: 385.34
Formula: C20 H14 F3 N3 O2
CAS Number: 1569076-11-4
InChi Key: LWBFIOPAFDTCND-UHFFFAOYSA-N
InChi: InChI=1S/C20H14F3N3O2/c21-20(22,23)14-9-7-13(8-10-14)12-26-16-5-2-1-4-15(16)18(25-26)24-19(27)17-6-3-11-28-17/h1-11H,12H2,(H,24,25,27)
Smiles: O=C(NC1=NN(CC2C=CC(=CC=2)C(F)(F)F)C2=CC=CC=C21)C1=CC=CO1
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power
Shelf Life: 1.0 years
Formula: C20 H14 F3 N3 O2
CAS Number: 1569076-11-4
InChi Key: LWBFIOPAFDTCND-UHFFFAOYSA-N
InChi: InChI=1S/C20H14F3N3O2/c21-20(22,23)14-9-7-13(8-10-14)12-26-16-5-2-1-4-15(16)18(25-26)24-19(27)17-6-3-11-28-17/h1-11H,12H2,(H,24,25,27)
Smiles: O=C(NC1=NN(CC2C=CC(=CC=2)C(F)(F)F)C2=CC=CC=C21)C1=CC=CO1
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power
Shelf Life: 1.0 years
Description:
FASCIN-G2 is a potent, selective and bioavailable small molecule that inhibits the actin-bundling activity of fascin with Kd ~5-20 µM. It specifically blocks filopodial formation, tumour cell migration and invasion in vitro. , FASCIN-G2 showed very good in vivo efficacy in 4T1 mammary tumour metastasis model and in MDA-MB-231 human breast tumour metastasis model.
Size: 2 mg solid,10 mg solid 2 mg solid,10 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.