bs-60268C
[Life Science]
SBI-0206965 --- Autophagy Kinase ULK1 Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 489.32
Formula: C21 H21 Br N4 O5
CAS Number: 1884220-36-3
InChi Key: NEXGBSJERNQRSV-UHFFFAOYSA-N
InChi: InChI=1S/C21H21BrN4O5/c1-23-19(27)13-7-5-6-8-15(13)31-20-14(22)11-24-21(26-20)25-12-9-16(28-2)18(30-4)17(10-12)29-3/h5-11H,1-4H3,(H,23,27)(H,24,25,26)
Smiles: CNC(=O)C1C=CC=CC=1OC1=NC(NC2C=C(OC)C(OC)=C(C=2)OC)=NC=C1Br
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C21 H21 Br N4 O5
CAS Number: 1884220-36-3
InChi Key: NEXGBSJERNQRSV-UHFFFAOYSA-N
InChi: InChI=1S/C21H21BrN4O5/c1-23-19(27)13-7-5-6-8-15(13)31-20-14(22)11-24-21(26-20)25-12-9-16(28-2)18(30-4)17(10-12)29-3/h5-11H,1-4H3,(H,23,27)(H,24,25,26)
Smiles: CNC(=O)C1C=CC=CC=1OC1=NC(NC2C=C(OC)C(OC)=C(C=2)OC)=NC=C1Br
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
SBI-0206965 is a potent and selective autophagy Kinase ULK1 Inhibitor. Many tumors become addicted to autophagy for survival, suggesting inhibition of autophagy as a potential broadly applicable cancer therapy. SBI-0206965 is a highly selective ULK1 kinase inhibitor in vitro and suppressed ULK1-mediated phosphorylation events in cells, regulating autophagy and cell survival. SBI-0206965 greatly synergized with mechanistic target of rapamycin (mTOR) inhibitors to kill tumor cells, providing a strong rationale for their combined use in the clinic.
Size: 2 mg solid, 10mg solid2 mg solid, 10mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.