bs-60264C
[Life Science]
PFI-4, BRPF1 Bromodomain Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 380.44
Formula: C21 H24 N4 O3
CAS Number: 900305-37-5
InChi Key: QCIJLRJBZDBVDB-UHFFFAOYSA-N
InChi: InChI=1S/C21H24N4O3/c1-23-17-12-15(22-20(26)14-8-4-5-9-19(14)28-3)16(25-10-6-7-11-25)13-18(17)24(2)21(23)27/h4-5,8-9,12-13H,6-7,10-11H2,1-3H3,(H,22,26)
Smiles: COC1C=CC=CC=1C(=O)NC1=CC2=C(C=C1N1CCCC1)N(C)C(=O)N2C
Purity: 98.0
Solubility: DMSO up to 50 mM, EtOH up to 10 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C21 H24 N4 O3
CAS Number: 900305-37-5
InChi Key: QCIJLRJBZDBVDB-UHFFFAOYSA-N
InChi: InChI=1S/C21H24N4O3/c1-23-17-12-15(22-20(26)14-8-4-5-9-19(14)28-3)16(25-10-6-7-11-25)13-18(17)24(2)21(23)27/h4-5,8-9,12-13H,6-7,10-11H2,1-3H3,(H,22,26)
Smiles: COC1C=CC=CC=1C(=O)NC1=CC2=C(C=C1N1CCCC1)N(C)C(=O)N2C
Purity: 98.0
Solubility: DMSO up to 50 mM, EtOH up to 10 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
PFI-4 is a potent, selective and cell permeable BRPF1 bromodomain inhibitor. It binds to BRPF1B with a Kd of 13 nM (ITC). It has general >100-fold selectivity against other bromodomains including BRPF2, BRPF3 and BRD4. It reduces recovery time in triple BRD cell construct in FRAP and is potent in cells with IC50 250 nM, while showing no effect on BRPF1A.
Size: 2 mg solid, 10mg solid2 mg solid, 10mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.