bs-60256C
[Life Science]
Furamidine dihydrochloride --- PRMT1 Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 377.27
Formula: C18 H18 Cl2 N4 O
CAS Number: 55368-40-6
InChi Key: VXNYQUQHOUERTR-UHFFFAOYSA-N
InChi: InChI=1S/C18H16N4O.2ClH/c19-17(20)13-5-1-11(2-6-13)15-9-10-16(23-15)12-3-7-14(8-4-12)18(21)22;;/h1-10H,(H3,19,20)(H3,21,22);2*1H
Smiles: Cl.Cl.NC(=N)C1C=CC(=CC=1)C1=CC=C(O1)C1C=CC(=CC=1)C(N)=N
Purity: 98.0
Solubility: DMSO and water up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C18 H18 Cl2 N4 O
CAS Number: 55368-40-6
InChi Key: VXNYQUQHOUERTR-UHFFFAOYSA-N
InChi: InChI=1S/C18H16N4O.2ClH/c19-17(20)13-5-1-11(2-6-13)15-9-10-16(23-15)12-3-7-14(8-4-12)18(21)22;;/h1-10H,(H3,19,20)(H3,21,22);2*1H
Smiles: Cl.Cl.NC(=N)C1C=CC(=CC=1)C1=CC=C(O1)C1C=CC(=CC=1)C(N)=N
Purity: 98.0
Solubility: DMSO and water up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
Furamidine is a potent, selective and cell permeable Protein arginine methyltransferase-1 (PRMT1) inhibitor with IC50 of 9.4 µM. It has >10-fold selectivity PRMT5, PRMT6 and CARM1 (IC50 are 166, 283 and >400 μM respectively). It targets the enzyme active site and is primarily competitive with the substrate and noncompetitive toward the cofactor. Furamidine effectively inhibits intracellular PRMT1 activity and blocks cell proliferation in leukemia cell lines with different genetic lesions.
Size: 10mg solid, 2mg solid 10mg solid, 2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.