bs-60255C
[Life Science]
OICR9429 --- WDR5 Antagonist
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 555.59
Formula: C29 H32 F3 N5 O3
CAS Number: 1801787-56-3
InChi Key: DJOVLOYCGXNVPI-UHFFFAOYSA-N
InChi: InChI=1S/C29H32F3N5O3/c1-35-7-9-37(10-8-35)26-6-5-22(21-4-2-3-20(15-21)19-36-11-13-40-14-12-36)16-25(26)34-28(39)23-18-33-27(38)17-24(23)29(30,31)32/h2-6,15-18H,7-14,19H2,1H3,(H,33,38)(H,34,39)
Smiles: CN1CCN(CC1)C1C=CC(=CC=1NC(=O)C1=CNC(=O)C=C1C(F)(F)F)C1=CC(CN2CCOCC2)=CC=C1
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C29 H32 F3 N5 O3
CAS Number: 1801787-56-3
InChi Key: DJOVLOYCGXNVPI-UHFFFAOYSA-N
InChi: InChI=1S/C29H32F3N5O3/c1-35-7-9-37(10-8-35)26-6-5-22(21-4-2-3-20(15-21)19-36-11-13-40-14-12-36)16-25(26)34-28(39)23-18-33-27(38)17-24(23)29(30,31)32/h2-6,15-18H,7-14,19H2,1H3,(H,33,38)(H,34,39)
Smiles: CN1CCN(CC1)C1C=CC(=CC=1NC(=O)C1=CNC(=O)C=C1C(F)(F)F)C1=CC(CN2CCOCC2)=CC=C1
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
OICR9429 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist (Kd ~24-52 nM). It has >100-fold selectivity over other methyltransferases tested. It disrupts WDR5 interaction with peptide regions of MLL and Histone 3. OICR-9429 also disrupts the interaction of WDR5 with MLL1 and RbBP5 in cells with IC50 values below 1 µM.
Size: 2 mg solid, 10mg solid2 mg solid, 10mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.