bs-60249C
[Life Science]
A01 --- Smurf1 E3 Ubiquitin Ligase Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 512.93
Formula: C22 H20 Cl F3 N4 O3 S
CAS Number: 1007647-73-5
InChi Key: QFYLTUDRXBNZFQ-UHFFFAOYSA-N
InChi: InChI=1S/C22H20ClF3N4O3S/c1-15-8-9-27-30(15)17-4-2-16(3-5-17)21(31)28-10-12-29(13-11-28)34(32,33)18-6-7-20(23)19(14-18)22(24,25)26/h2-9,14H,10-13H2,1H3
Smiles: CC1=CC=NN1C1C=CC(=CC=1)C(=O)N1CCN(CC1)S(=O)(=O)C1=CC(=C(Cl)C=C1)C(F)(F)F
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C22 H20 Cl F3 N4 O3 S
CAS Number: 1007647-73-5
InChi Key: QFYLTUDRXBNZFQ-UHFFFAOYSA-N
InChi: InChI=1S/C22H20ClF3N4O3S/c1-15-8-9-27-30(15)17-4-2-16(3-5-17)21(31)28-10-12-29(13-11-28)34(32,33)18-6-7-20(23)19(14-18)22(24,25)26/h2-9,14H,10-13H2,1H3
Smiles: CC1=CC=NN1C1C=CC(=CC=1)C(=O)N1CCN(CC1)S(=O)(=O)C1=CC(=C(Cl)C=C1)C(F)(F)F
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
A01 is a potent and selective Smurf1 E3 ubiquitin ligase inhibitor with Kd ~3.7 nM. It attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. It also potentiates BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells.
Size: 2 mg solid, 10mg solid2 mg solid, 10mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.