bs-60247C
[Life Science]
Verteporfin (Visudyne) --- YAP Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 718.79
Formula: C41 H42 N4 O8
CAS Number: 129497-78-5
InChi Key: YTZALCGQUPRCGW-MXVXOLGGSA-N
InChi: InChI=1S/C41H42N4O8/c1-9-23-20(2)29-17-34-27-13-10-26(39(49)52-7)38(40(50)53-8)41(27,5)35(45-34)19-30-22(4)25(12-15-37(48)51-6)33(44-30)18-32-24(11-14-36(46)47)21(3)28(43-32)16-31(23)42-29/h9-10,13,16-19,38,42,44H,1,11-12,14-15H2,2-8H3,(H,46,47)/b28-16-,29-17-,30-19-,31-16-,32-18-,33-18-,34-17-,35-19-/t38-,41+/m0/s1
Smiles: COC(=O)CCC1=C2C=C3N=C(C=C4NC(=CC5=NC(=CC(N2)=C1C)[C@]1(C)[C@@H](C(=CC=C15)C(=O)OC)C(=O)OC)C(C)=C4C=C)C(C)=C3CCC(O)=O
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C41 H42 N4 O8
CAS Number: 129497-78-5
InChi Key: YTZALCGQUPRCGW-MXVXOLGGSA-N
InChi: InChI=1S/C41H42N4O8/c1-9-23-20(2)29-17-34-27-13-10-26(39(49)52-7)38(40(50)53-8)41(27,5)35(45-34)19-30-22(4)25(12-15-37(48)51-6)33(44-30)18-32-24(11-14-36(46)47)21(3)28(43-32)16-31(23)42-29/h9-10,13,16-19,38,42,44H,1,11-12,14-15H2,2-8H3,(H,46,47)/b28-16-,29-17-,30-19-,31-16-,32-18-,33-18-,34-17-,35-19-/t38-,41+/m0/s1
Smiles: COC(=O)CCC1=C2C=C3N=C(C=C4NC(=CC5=NC(=CC(N2)=C1C)[C@]1(C)[C@@H](C(=CC=C15)C(=O)OC)C(=O)OC)C(C)=C4C=C)C(C)=C3CCC(O)=O
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
Verteporfin (Visudyne) is a potent and selective YAP inhibitor, disrupts YAP-TEAD interactions and enhances trypsin cleavage of YAP with EC50 ~100 nM. It inhibits growth and proliferation of retinoblastoma cells. It also significantly blocks cancer stem cell (CSC) properties in cells with high YAP1 and a high proportion of ALDH1(+). In vivo it can suppress YAP-induced liver overgrowth in mice.
Size: 10mg solid, 2 mg solid10mg solid, 2 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.