DATASHEET
Formulation
Powder
Storage:
Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 378.87
Formula: C14 H23 Cl N4 O4 S
CAS Number: 1784-03-8
InChi Key: JIQFFACVQXXHMY-YDALLXLXSA-N
InChi: InChI=1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H/t12-;/m0./s1
Smiles: Cl.CC1C=CC(=CC=1)S(=O)(=O)N[C@@H](CCCNC(N)=N)C(=O)OC
Purity: 98.0
Solubility: DMSO and water up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
TAME is a competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C). It promotes Cdc20 autoubiquitination and inhibits cyclin proteolysis in mitotic Xenopus oocyte extracts (IC50 ~ 12 μM) and blocks cyclin degradation in interphase extract.