bs-60245C
[Life Science]
PRT4165 --- E3 Ubiquitin-ligase Bmi1/Ring1A Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 235.24
Formula: C15 H9 N O2
CAS Number: 31083-55-3
InChi Key: OMHZFEWYVFWVLI-UHFFFAOYSA-N
InChi: InChI=1S/C15H9NO2/c17-14-11-5-1-2-6-12(11)15(18)13(14)8-10-4-3-7-16-9-10/h1-9H
Smiles: O=C1C(=CC2C=NC=CC=2)C(=O)C2=CC=CC=C12
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C15 H9 N O2
CAS Number: 31083-55-3
InChi Key: OMHZFEWYVFWVLI-UHFFFAOYSA-N
InChi: InChI=1S/C15H9NO2/c17-14-11-5-1-2-6-12(11)15(18)13(14)8-10-4-3-7-16-9-10/h1-9H
Smiles: O=C1C(=CC2C=NC=CC=2)C(=O)C2=CC=CC=C12
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
PRT4165 is a small molecule inhibitor of polycomb repressive complex 1, which inhibits ubiquitin signaling at DNA double-strand breaks. PRT4165 is a potent inhibitor of PRC1-mediated H2A ubiquitylation in vivo and in vitro. The drug also inhibits the accumulation of all detectable ubiquitin at sites of DNA double-strand breaks (DSBs), the retention of several DNA damage response proteins in foci that form around DSBs, and the repair of the DSBs.
Size: 2 mg solid, 10mg solid2 mg solid, 10mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.