bs-60244C
[Life Science]
HBX41108, USP7 Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 266.64
Formula: C13 H3 Cl N4 O
CAS Number: 924296-39-9
InChi Key: BIGPXXAUSQLTQR-UHFFFAOYSA-N
InChi: InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H
Smiles: N#CC1N=C2C(=NC=1C#N)C(=O)C1C=C(Cl)C=CC=12
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C13 H3 Cl N4 O
CAS Number: 924296-39-9
InChi Key: BIGPXXAUSQLTQR-UHFFFAOYSA-N
InChi: InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H
Smiles: N#CC1N=C2C(=NC=1C#N)C(=O)C1C=C(Cl)C=CC=12
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
HBX41108 is a potent and selective ubiquitin-specific protease 7 (USP7) inhibitor with IC50 ~424 nM. Kinetics data indicate it is an uncompetitive reversible inhibition mechanism. It inhibits USP7-mediated p53 deubiquitination (IC50 ~0.8 μM). It can also stabilize p53 and activate the transcription of a p53 target gene without inducing genotoxic stress. HBX41108 inhibits cancer cell growth, and induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.
Size: 2 mg solid, 10 mg solid 2 mg solid, 10 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.