bs-60234C
[Life Science]
CAY10603 --- HDAC6 Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 446.5
Formula: C22 H30 N4 O6
CAS Number: 1045792-66-2
InChi Key: WWGBHDIHIVGYLZ-UHFFFAOYSA-N
InChi: InChI=1S/C22H30N4O6/c1-22(2,3)31-21(29)24-16-11-9-15(10-12-16)18-14-17(26-32-18)20(28)23-13-7-5-4-6-8-19(27)25-30/h9-12,14,30H,4-8,13H2,1-3H3,(H,23,28)(H,24,29)(H,25,27)
Smiles: CC(C)(C)OC(=O)NC1C=CC(=CC=1)C1=CC(=NO1)C(=O)NCCCCCCC(=O)NO
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C22 H30 N4 O6
CAS Number: 1045792-66-2
InChi Key: WWGBHDIHIVGYLZ-UHFFFAOYSA-N
InChi: InChI=1S/C22H30N4O6/c1-22(2,3)31-21(29)24-16-11-9-15(10-12-16)18-14-17(26-32-18)20(28)23-13-7-5-4-6-8-19(27)25-30/h9-12,14,30H,4-8,13H2,1-3H3,(H,23,28)(H,24,29)(H,25,27)
Smiles: CC(C)(C)OC(=O)NC1C=CC(=CC=1)C1=CC(=NO1)C(=O)NCCCCCCC(=O)NO
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
CAY10603 is a potent and selective HDAC6 inhibitor with IC50 of 2 pM. It has 271 nM, 252 nM, 0.42 nM, 6851 nM, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively. CAY10603 has potent antiproliferative activity against pancreatic cancer cell lines with IC50 of <1 μM. It could be useful chemical probe to study HDAC biology.
Size: 2 mg solid,10 mg solid 2 mg solid,10 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.