bs-60231C
[Life Science]
HPOB --- HDAC6 Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 314.34
Formula: C17 H18 N2 O4
CAS Number: 1429651-50-2
InChi Key: RFAZNTABYJYOAR-UHFFFAOYSA-N
InChi: InChI=1S/C17H18N2O4/c20-11-10-19(15-4-2-1-3-5-15)16(21)12-13-6-8-14(9-7-13)17(22)18-23/h1-9,20,23H,10-12H2,(H,18,22)
Smiles: OCCN(C(=O)CC1C=CC(=CC=1)C(=O)NO)C1C=CC=CC=1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C17 H18 N2 O4
CAS Number: 1429651-50-2
InChi Key: RFAZNTABYJYOAR-UHFFFAOYSA-N
InChi: InChI=1S/C17H18N2O4/c20-11-10-19(15-4-2-1-3-5-15)16(21)12-13-6-8-14(9-7-13)17(22)18-23/h1-9,20,23H,10-12H2,(H,18,22)
Smiles: OCCN(C(=O)CC1C=CC(=CC=1)C(=O)NO)C1C=CC=CC=1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
HPOB is a potent and selective HDAC6 inhibitor with IC50 of 56 nM. It has >30-fold selectivity over other HDACs. It causes growth inhibition of normal and transformed cells but does not induce cell death. It enhances the effectiveness of DNA-damaging anticancer drugs in transformed cells but not normal cells. HPOB does not block the ubiquitin-binding activity of HDAC6. In mice bearing CWR22 human prostate cancer xenografts, when in combination with SAHA, HPOB causes suppression of the growth of established tumors, while produces no significant suppression when used alone.
Size: 2 mg solid,10 mg solid 2 mg solid,10 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.