bs-60229C
[Life Science]
Ischemin, CBP Bromodomain Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 357.36
Formula: C15 H16 N3 Na O4 S
CAS Number: 1357059-00-7
InChi Key: ZTDQQIATQGCZBV-ZAGWXBKKSA-M
InChi: InChI=1S/C15H17N3O4S.Na/c1-8-4-10(3)15(23(20,21)22)7-12(8)17-18-13-5-9(2)14(19)6-11(13)16;/h4-7,19H,16H2,1-3H3,(H,20,21,22);/q;+1/p-1/b18-17+;
Smiles: [Na+].CC1C=C(C)C(=CC=1S([O-])(=O)=O)/N=N/C1C=C(C)C(O)=CC=1N
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C15 H16 N3 Na O4 S
CAS Number: 1357059-00-7
InChi Key: ZTDQQIATQGCZBV-ZAGWXBKKSA-M
InChi: InChI=1S/C15H17N3O4S.Na/c1-8-4-10(3)15(23(20,21)22)7-12(8)17-18-13-5-9(2)14(19)6-11(13)16;/h4-7,19H,16H2,1-3H3,(H,20,21,22);/q;+1/p-1/b18-17+;
Smiles: [Na+].CC1C=C(C)C(=CC=1S([O-])(=O)=O)/N=N/C1C=C(C)C(O)=CC=1N
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
Ischemin is a potent, selective and cell permeable CBP bromodomain inhibitor. It inhibits the acetyl-lysine binding activity of the bromodomain of CBP. It alters post-translational modifications on p53 and histones, inhibits p53 interaction with CBP and transcriptional activity in cells, and prevents Doxorubicin-induced apoptosis in ischemic cardiomyocytes. Ischemin is a good chemical probe to modulate acetylation-mediated interactions in gene transcription and a new approach to therapeutic interventions of human disorders such as myocardial ischemia
Size: 2 mg solid, 10 mg solid 2 mg solid, 10 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.