bs-60199C
[Life Science]
PR-619 --- Deubiquitinylating Enzyme (DUB) Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 223.28
Formula: C7 H5 N5 S2
CAS Number: 2645-32-1
InChi Key: ZXOBLNBVNROVLC-UHFFFAOYSA-N
InChi: InChI=1S/C7H5N5S2/c8-2-13-4-1-5(14-3-9)7(11)12-6(4)10/h1H,(H4,10,11,12)
Smiles: NC1N=C(N)C(=CC=1SC#N)SC#N
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C7 H5 N5 S2
CAS Number: 2645-32-1
InChi Key: ZXOBLNBVNROVLC-UHFFFAOYSA-N
InChi: InChI=1S/C7H5N5S2/c8-2-13-4-1-5(14-3-9)7(11)12-6(4)10/h1H,(H4,10,11,12)
Smiles: NC1N=C(N)C(=CC=1SC#N)SC#N
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
PR-619 is a cell-permeable, non-selective, reversible broad-range inhibitor of the deubiquitinylating enzymes (DUBs) with IC50 of 1-20 μM. PR-619 is shown to increase overall protein polyubiquitination in HEK293T cells in a dose- and time-dependent manner (20 to 150 μM, 0.5 to 20 h) without direct impairment of proteasomal proteolysis. PR-619 treatment results in upregulation of both K48 - and K63-linked polyUb chains. It induces HCT116 cell death with EC50 ~6.3 μM.
Size: 2 mg solid, 10mg solid2 mg solid, 10mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.