bs-60195C
[Life Science]
IOX1 --- 2OG Oxygenases Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 189.17
Formula: C10 H7 N O3
CAS Number: 5852-78-8
InChi Key: JGRPKOGHYBAVMW-UHFFFAOYSA-N
InChi: InChI=1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
Smiles: OC1C=CC(=C2C=CC=NC=12)C(O)=O
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C10 H7 N O3
CAS Number: 5852-78-8
InChi Key: JGRPKOGHYBAVMW-UHFFFAOYSA-N
InChi: InChI=1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)
Smiles: OC1C=CC(=C2C=CC=NC=12)C(O)=O
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
IOX1 is a cell-permeable broad-spectrum inhibitor of most 2OG oxygenases. It inhibits histone demethylase JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX with IC50 at 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM respectively. IOX1 inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells.
Size: 2mg solid ,10 mg solid 2mg solid ,10 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.