DATASHEET
Formulation
Powder
Storage:
Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 336.43
Formula: C17 H28 N4 O3
CAS Number: 1596348-32-1
InChi Key: WCILOMUUNVPIKQ-UHFFFAOYSA-N
InChi: InChI=1S/C17H28N4O3/c1-5-21(10-9-20(3)4)16(22)13-18-12-15-11-14(7-8-19-15)17(23)24-6-2/h7-8,11,18H,5-6,9-10,12-13H2,1-4H3
Smiles: CN(C)CCN(CC)C(=O)CNCC1C=C(C=CN=1)C(=O)OCC
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
KDM5-C70 is an ethyl ester derivative of KDM5-C49, which is a potent and selective inhibitor of Jumonji AT-Rich Interactive Domain 1 (JARID1) histone demethylases. The highly polar carboxylate group of KDM5-C49 restricts its cellular permeability; therefore KDM5-C70 was developed as a pro-drug, masking the polarity of the acid group of the KDM5-C49, for cellular assays and in vivo use. KDM5-C70 increases H3K4me3 levels in myeloma cells. Treatment of MCF7 and MDA-MB-231 breast cancer cells with KDM5-C70 significantly increased global levels of H3K4me3 while having little impact on H3K4me2/me1 or modifications regulated by other histone lysine demethylases.
Size:
10mg solid, 2mg solid , 10 mM in DMSO (0.62010mg solid, 2mg solid , 10 mM in DMSO (0.620 mL)
Applications:
Life Science()
For research use only. Not intended for diagnostic or therapeutic use.