bs-60190C
[Life Science]
IDH2-C100, IHD2 Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 305.38
Formula: C18 H19 N5
CAS Number: 1446506-78-0
InChi Key: WVHMNCOFPWFUMF-UHFFFAOYSA-N
InChi: InChI=1S/C18H19N5/c1-13(2)19-17-21-16(14-9-5-3-6-10-14)22-18(23-17)20-15-11-7-4-8-12-15/h3-13H,1-2H3,(H2,19,20,21,22,23)
Smiles: CC(C)NC1N=C(NC2C=CC=CC=2)N=C(N=1)C1C=CC=CC=1
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C18 H19 N5
CAS Number: 1446506-78-0
InChi Key: WVHMNCOFPWFUMF-UHFFFAOYSA-N
InChi: InChI=1S/C18H19N5/c1-13(2)19-17-21-16(14-9-5-3-6-10-14)22-18(23-17)20-15-11-7-4-8-12-15/h3-13H,1-2H3,(H2,19,20,21,22,23)
Smiles: CC(C)NC1N=C(NC2C=CC=CC=2)N=C(N=1)C1C=CC=CC=1
Purity: 98.0
Solubility: DMSO up to 50 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
IDH2-C100 is a potent and selective inhibitor of IDH2 R140Q and R172K mutant first reported in patent WO 2013102431. It can inhibit the enzymatic activity of IDH2 R140Q and R172K in vitro with an IC50 < 0.1 µM. It has IC50 < 0.1 µM in U87MG pLVX-IDH2 R140Q-neo cell based assay. It is an analog of clinical IDH2 inhibitor AG-221 by Thomson Reuters Integrity analysis.
Size: 2mg solid ,10 mg solid 2mg solid ,10 mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.