bs-60189C

DATASHEET

Formulation Powder

Storage: Store in dry, dark place at -20C for 1 year.

Product Information:

Molecular Weight: 387.39

Formula: C17 H21 N7 O4

CAS Number: 326914-06-1

InChi Key: MSSXBKQZZINCRI-UHFFFAOYSA-N

InChi: InChI=1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H,5-12H2,(H,18,19,20,21)

Smiles: [O-][N+](=O)C1C=CC(=CC=1)NC1N=C(N=C(N=1)N1CCOCC1)N1CCOCC1

Purity: 98.0

Solubility: DMSO up to 10 mM

Appearance: Solid Power.

Shelf Life: 1.0 years

Description:

MHY1485 is a novel potent, selective and cell-permeable mTOR activator. It suppressed the basal autophagic flux, and this inhibitory effect was clearly confirmed in cells under starvation, a strong physiological inducer of autophagy. It can increase cellular mTOR Ser2448 and downstream substrate 4E-BP Thr37/46 phosphorylation level in rat liver Ac2F cells (1 to 2 µM for 1 h). It affects culture viability only at much higher concentrations (by 20% after 24 h 20 µM treatment). MHY1485 induced cellular LC3-II accumulation in Ac2F is reported to be a result of autophagy inhibition due to reduced fusion between autophagosomes and lysosomes. MHY1485 serves as a novel inhibitor of autophagy with an mTOR activating effect.