bs-60183C
[Life Science]
ML324 --- JMJD2 Histone Demethylase Inhibitor
DATASHEET
Formulation Powder
Storage: Store in dry, dark place at -20C for 1 year.
Product Information:
Molecular Weight: 349.43
Formula: C21 H23 N3 O2
CAS Number: 1222800-79-4
InChi Key: QDBVSOZTVKXUES-UHFFFAOYSA-N
InChi: InChI=1S/C21H23N3O2/c1-24(2)12-4-11-23-21(26)16-8-6-15(7-9-16)18-13-17-5-3-10-22-20(17)19(25)14-18/h3,5-10,13-14,25H,4,11-12H2,1-2H3,(H,23,26)
Smiles: CN(C)CCCNC(=O)C1C=CC(=CC=1)C1=CC(O)=C2N=CC=CC2=C1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Formula: C21 H23 N3 O2
CAS Number: 1222800-79-4
InChi Key: QDBVSOZTVKXUES-UHFFFAOYSA-N
InChi: InChI=1S/C21H23N3O2/c1-24(2)12-4-11-23-21(26)16-8-6-15(7-9-16)18-13-17-5-3-10-22-20(17)19(25)14-18/h3,5-10,13-14,25H,4,11-12H2,1-2H3,(H,23,26)
Smiles: CN(C)CCCNC(=O)C1C=CC(=CC=1)C1=CC(O)=C2N=CC=CC2=C1
Purity: 98.0
Solubility: DMSO up to 100 mM
Appearance: Solid Power.
Shelf Life: 1.0 years
Description:
ML324 is a potent, selective and cell permeable inhibitor of Jumonji domain-containing protein 2 (JMJD2) histone demethylase with IC50 ~0.92 µM toward JMJD2E. It has excellent in vitro ADME properties, and it could effectively block both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression. ML324 suppresses the formation of HSV plaques, even at high MOI, and blocks HSV-1 reactivation in a mouse ganglia explant model of latently infected mice.
Size: 10mg solid,2mg solid 10mg solid,2mg solid
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.